{"id":23960,"date":"2026-07-15T00:23:20","date_gmt":"2026-07-14T22:23:20","guid":{"rendered":"https:\/\/www.ngdcare.nl\/product\/uncategorized\/lever-support-bundle\/"},"modified":"2026-08-02T21:35:30","modified_gmt":"2026-08-02T19:35:30","slug":"lever-support-bundle","status":"publish","type":"product","link":"https:\/\/www.ngdcare.nl\/en\/product\/bundles\/lever-support-bundle\/","title":{"rendered":"Lever Support Bundle"},"content":{"rendered":"
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Your animal has received elevated liver values, liver disease or a diagnosis such as fatty liver, hepatitis or liver insufficiency.<\/strong> This bundle has been developed as a supplement to your vet’s treatment. We explain what is really going on in your animal’s liver, what the regular approach lacks and what we recommend to protect the liver tissue and promote recovery. <\/p>\n<\/div>\n

What your vet told you, and what else is going on<\/h2>\n

Your veterinarian has measured elevated liver enzymes, possibly made an ultrasound, and prescribed liver-supporting medication. That is justified. But in an average consultation, there is no room to explain why liver disease is so much more than a liver problem, and why the organ that does the most work in the body also deserves the most help with recovery. <\/p>\n

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What your vet may not have explained<\/p>\n

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\u2192<\/span>The liver is the only organ with the ability to regenerate. But that regenerative capacity needs the right conditions: sufficient glutathione, no oxidative overload, no sustained ignition drivers. <\/div>\n
\u2192<\/span>Liver disease almost always starts in the intestine. LPS from a disrupted intestinal barrier reaches the liver directly through the portal vein and activates Kupffer cells, accelerating hepatic inflammation and fibrosis. <\/div>\n
\u2192<\/span>Fibrosis is the common endpoint of all chronic liver diseases. TGF-\u03b21 converts liver cells into scar tissue. In early stages, this can be influenced. <\/div>\n
\u2192<\/span>The liver has the highest glutathione requirement of any organ in the body. In liver disease, glutathione is structurally depleted, which further lowers the detoxification capacity in a vicious cycle. <\/div>\n
\u2192<\/span>Ultra-processed dry food increases the toxin load on the liver on a daily basis via processed fats, synthetic additives and mycotoxins in grains. This undermines any recovery process. <\/div>\n
\u2192<\/span>Silymarin from milk thistle is the best-founded hepatoprotective supplement available. It will be available in the NGD Care range this year. <\/div>\n<\/div>\n<\/div>\n

Nutrition for liver disease: what we recommend<\/h2>\n

In liver disease, a low-protein diet is often recommended to limit ammonia production. From the point of view of integrative medicine, Stefan Veenstra DVM has a nuanced point of view on this. <\/p>\n

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Our nutritional advice for liver disease<\/p>\n

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No ultra-processed dry food.<\/strong> Dry food increases the daily toxin load on the liver through processed fats, mycotoxins in grains and synthetic additives. The liver has to filter everything that is absorbed through the gastrointestinal tract. Ultra-processed ingredients structurally prolong detoxification work. <\/div>\n
High-quality fresh protein sources.<\/strong> In liver disease without severe hepatic encephalopathy, protein restriction is not indicated and impairs it. The liver needs amino acids for hepatocyte regeneration, for glutathione synthesis and for albumin production. Protein restriction in an already weakened liver immediately slows down recovery. Protein restriction is only indicated in case of demonstrable hepatic encephalopathy, always in consultation with the veterinarian. <\/div>\n
Fresh varied protein sources.<\/strong> Plant-based protein sources such as soy produce fewer ammonia precursors than animal proteins in fermentation. In practice, we recommend a mix of high-quality animal proteins with sufficient fermentable fibers that dampen the ammonia-forming bacteria in the intestine. <\/div>\n
20% ground vegetables.<\/strong> Cruciferous vegetables such as broccoli and Brussels sprouts contain glucosinolates that activate phase II detoxification enzymes in the liver via Nrf2. This is direct nutritional support of liver function. <\/div>\n<\/div>\n<\/div>\n

Three mechanisms that drive liver disease<\/h2>\n
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1. Oxidative stress<\/div>\n

The liver is the primary detoxification organ and produces ROS structurally. In liver disease, ROS production exceeds glutathione capacity, causing hepatocyte damage and DNA damage. <\/p>\n<\/div>\n

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2. TGF-\u03b21-fibrosis<\/div>\n

TGF-\u03b21 activates hepatic stellate cells that produce collagen and convert liver parenchyma into scar tissue. Fibrosis is the endpoint of all chronic liver diseases. <\/p>\n<\/div>\n

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3. Intestine-liver axis<\/div>\n

LPS from a disrupted intestinal barrier reaches the liver directly through the portal vein and activates Kupffer cells. This is the primary external driver of hepatic inflammation and fibrosis. <\/p>\n<\/div>\n<\/div>\n

Our advice: phased support in addition to the care of your veterinarian<\/h2>\n

The phasing is mechanistically: first stabilize the gut-liver axis and reduce the toxin supply, then actively protect the liver and inhibit fibrosis, then restore the mitochondria for sustainable liver regeneration.<\/p>\n

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1<\/div>\n
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Phase 1: Stabilize the gut-liver axis, weeks 1 to 6<\/div>\n
Reducing the toxin supply at source<\/div>\n<\/div>\n<\/div>\n

The portal vein connects the intestine directly to the liver. Everything that is absorbed in the intestine, including LPS from a disturbed intestinal barrier, reaches the liver first. Prebiotics reduce LPS-producing dysbiosis. Enzyme mix 2 improves digestion so that undigested proteins in the colon ferment less into ammonia. Liposomal curcumin inhibits NF-kB and TGF-\u03b21, thereby addressing two of the three central fibrosis drivers simultaneously. Vitamin C as a cofactor for glutathione synthesis and phase I detoxification enzymes. <\/p>\n

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We advise in phase 1<\/div>\n
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\u2192<\/span> Prebiotics<\/div>\n
\u2192<\/span> Enzyme Mix 2<\/div>\n
\u2192<\/span> Liposomal Vitamin C<\/div>\n
\u2192<\/span> Liposomal Curcumin<\/div>\n<\/div>\n<\/div>\n<\/div>\n

<\/p>\n

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2<\/div>\n
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Phase 2: Liver Protection and Anti-Fibrosis, Weeks 6 to 14<\/div>\n
Restore glutathione, inhibit fibrosis, improve fat oxidation<\/div>\n<\/div>\n<\/div>\n

Liposomal glutathione is the core of phase 2. The liver has the highest glutathione requirement of any organ. Glutathione neutralizes ROS, is essential for phase II detoxification via glutathione-S-transferase and protects hepatocytes from toxic damage. Para Reset delivers the glutathione precursor cysteine for endogenous supplementation via NAC, and AMPK activation via berberine that stimulates fat oxidation in hepatocytes and inhibits lipid accumulation in fatty liver disease. Omega-3 modulates Kupffer cell macrophage balance and lowers hepatic TNF-alpha and IL-6 production. <\/p>\n

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We advise in phase 2<\/div>\n
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\u2192<\/span> Liposomal Glutathione<\/div>\n
\u2192<\/span> Para Reset (berberine + NAC)<\/div>\n
\u2192<\/span> Omega-3 Calanus Oil<\/div>\n
\u2192<\/span> Silymarine* (coming soon)<\/div>\n<\/div>\n

* Silymarin (milk thistle) is the best-researched hepatoprotective supplement available. It will be added to the NGD Care range this year and will then be part of phase 2 as a core support. <\/p>\n<\/div>\n<\/div>\n

<\/p>\n

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3<\/div>\n
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Phase 3: Mitochondrial repair and liver regeneration, weeks 14 to 22<\/div>\n
Restoring energy production of hepatocytes for sustainable regeneration<\/div>\n<\/div>\n<\/div>\n

Liver regeneration is an energy-consuming process. Hepatocytes that create new liver parenchyma need a high mitochondrial capacity. Longevity Support restores sirtuin activity and mitochondrial biogenesis through NAD\u207a. SIRT1 and SIRT3 activation additionally improves liver fat oxidation via PGC-1alpha and decreases hepatic lipid accumulation. CoQ10 restores the electron transport chain and is structurally reduced in chronic liver disease due to oxidative depletion. <\/p>\n

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We advise in phase 3<\/div>\n
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\u2192<\/span> Longevity Support<\/div>\n
\u2192<\/span> Liposomal CoQ10<\/div>\n
\u2192<\/span> Liposomal Glutathione<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

<\/p>\n

What can you expect and when?<\/h2>\n

The liver is the only organ with the ability to regenerate, but recovery takes time. Check liver enzymes (ALT, AST, ALP, GGT) every 6 to 8 weeks with the veterinarian to objectively monitor progress. <\/p>\n

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Weeks 1-6<\/div>\n

Intestine stabilized. Toxin supply at source reduced. Reduced systemic LPS burden on the liver. <\/p>\n<\/div>\n

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Week 6-14<\/div>\n

Glutathione restored. Fibrosis slowed down. Possible improvement in liver enzymes visible when controlled. <\/p>\n<\/div>\n

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Week 14-22<\/div>\n

Mitochondrial repair. More vitality, better appetite, coat improves. Liver regeneration underway. <\/p>\n<\/div>\n

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Month 6+<\/div>\n

Liver enzymes stabilized or normalized. Maintenance with glutathione, curcumin and prebiotics. <\/p>\n<\/div>\n<\/div>\n

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Check liver enzymes every 6 to 8 weeks. In case of liver cirrhosis, portosystemic shunt or liver insufficiency, always schedule a personal consultation for tailor-made advice. Some supplements require dose adjustment in case of reduced liver detoxification capacity. <\/p>\n<\/div>\n

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In addition to specific complaints<\/h2>\n
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Nausea and poor appetite<\/div>\n

Increased bilirubin and bile acid accumulation cause nausea through the central nervous system. CBD oil modulates the endocannabinoid system and has an antiemetic effect without liver strain. <\/p>\n

\u2192<\/span> CBD oil<\/div>\n<\/div>\n
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Ascites and fluid congestion<\/div>\n

Fluid leakage occurs with reduced albumin production by the liver. Always veterinary guidance. Dandelion as a supportive diuretic herbal support in addition to medication. <\/p>\n

\u2192<\/span> Consultation required<\/div>\n<\/div>\n
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Itching due to bile acid accumulation<\/div>\n

Cholestasis leads to bile acid accumulation in the skin with severe itching. PEA & Boswellia inhibits neuroinflammation and mast cell activation that increase itching. <\/p>\n

\u2192<\/span> PEA & Boswellia<\/div>\n<\/div>\n
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Fatigue and muscle weakness<\/div>\n

Decreased glycogen storage and metabolic hepatic insufficiency cause chronic fatigue. Liposomal vitamin B complex replenishes the B vitamins that the liver normally stores and converts. <\/p>\n

\u2192<\/span> Liposomal Vitamin B Complex<\/div>\n<\/div>\n<\/div>\n
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In severe hepatic impairment, some supplements may require an adjusted dosage because the liver metabolizes them. When in doubt, always schedule a personal consultation for tailor-made advice. <\/p>\n<\/div>\n

<\/p>\n

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For which situations do we recommend this bundle?<\/p>\n

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\u2713<\/span>Elevated liver enzymes (ALT, AST, ALP, GGT)<\/div>\n
\u2713<\/span>Fatty liver disease (hepatic lipidosis)<\/div>\n
\u2713<\/span>Hepatitis (infectious or autoimmune)<\/div>\n
\u2713<\/span>Early liver fibrosis or cirrhosis<\/div>\n
\u2713<\/span>Cholangitis or bile duct disease<\/div>\n
\u2713<\/span>Support with toxic liver load or medication use<\/div>\n
\u2713<\/span>Preventive in breeds with liver predisposition (Dalmatian, Bedlington Terrier)<\/div>\n
\u2713<\/span>Recovery after acute liver disease<\/div>\n<\/div>\n<\/div>\n
[trustindex no-registration=”google”]<\/div>\n
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Want to read the full scientific background?<\/p>\n

Stefan Veenstra DVM explains how the gut-liver axis, oxidative stress, TGF-\u03b21-fibrosis and silymarin are related to liver disease in dogs and cats.<\/p>\n<\/div>\n

Read the article<\/a><\/p>\n<\/div>\n

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All supplements in this bundle<\/p>\n

\u2192<\/span> Prebiotics<\/a>
\n\u2192<\/span> Enzyme Mix 2<\/a>
\n\u2192<\/span> Liposomal Vitamin C<\/a>
\n\u2192<\/span> Liposomal Curcumin<\/a>
\n\u2192<\/span> Liposomal Glutathione<\/a>
\n\u2192<\/span> Para Reset (berberine + NAC)<\/a>
\n\u2192<\/span> Omega-3 Calanus Oil<\/a>
\n\u2192<\/span> Longevity Support<\/a>
\n\u2192<\/span> Liposomal CoQ10<\/a>
\n\u2192<\/span> Silymarine (coming soon)<\/a><\/div>\n<\/div>\n
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SV<\/div>\n

Developed and clinically substantiated by Stefan Veenstra DVM<\/strong>, integrative veterinarian and founder of NGD Care. For personal guidance: NGD Care consultation \u2192<\/a> <\/p>\n<\/div>\n

This bundle is educational in nature and does not replace a veterinary consultation. The Liver Support Bundle is intended as a supplement to regular veterinary treatment, never as a replacement. In case of liver cirrhosis, portosystemic shunt or severe liver insufficiency, always schedule a personal consultation. Some supplements require dose adjustment in case of reduced liver detoxification capacity. <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Additional supplementation support for elevated liver values, fatty liver, hepatitis and liver fibrosis in dogs and cats. Targeting the gut-liver axis, glutathione repair and anti-fibrosis. Silymarin will be added this year as a core support through the NGD Care Vet Pro Line. <\/p>\n","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"wds_primary_product_brand":0,"wds_primary_product_cat":0,"wds_primary_merken":0,"_members_access_role":[],"_members_access_error":""},"product_brand":[],"product_cat":[13839,13861],"product_tag":[13902,132,270,13886,6104,13890,13896,13888,13900,13892,272,13894,13898],"merken":[],"class_list":["post-23960","product","type-product","status-publish","product_cat-bundles","product_cat-kidney-liver","product_tag-alt-ast-alp","product_tag-curcumin","product_tag-detox-en","product_tag-fatty-liver","product_tag-glutathione","product_tag-hepatitis","product_tag-intestine-liver-axis","product_tag-liver-disease","product_tag-liver-enzymes","product_tag-liver-fibrosis","product_tag-nac-en","product_tag-silymarin","product_tag-tgf-1","infinite-scroll-item","sales-flash-overlay","woocommerce-text-align-center","woocommerce-image-align-center","do-quantity-buttons","first","instock","taxable","shipping-taxable","product-type-grouped"],"meta_box":[],"_links":{"self":[{"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/product\/23960","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/comments?post=23960"}],"wp:attachment":[{"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/media?parent=23960"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/product_brand?post=23960"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/product_cat?post=23960"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/product_tag?post=23960"},{"taxonomy":"merken","embeddable":true,"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/merken?post=23960"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}