{"id":24722,"date":"2026-08-08T22:28:08","date_gmt":"2026-08-08T20:28:08","guid":{"rendered":"https:\/\/www.ngdcare.nl\/product\/uncategorized\/endocrine-support-bundle\/"},"modified":"2026-08-08T22:28:08","modified_gmt":"2026-08-08T20:28:08","slug":"endocrine-support-bundle","status":"publish","type":"product","link":"https:\/\/www.ngdcare.nl\/en\/product\/bundles\/endocrine-support-bundle\/","title":{"rendered":"Endocrine support bundle"},"content":{"rendered":"
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Your animal has received a hormonal diagnosis: hypothyroidism, hyperthyroidism, Cushing’s disease or Addison’s disease.<\/strong> Or you recognize the signs of hormonal dysregulation without a formal diagnosis. This bundle has been developed as a supplement to your vet’s treatment. We explain what is really going on in your animal’s body, what the medication does and what we recommend to support the system around it. <\/p>\n<\/div>\n

What your vet told you, and what else is going on<\/h2>\n

Your vet has diagnosed a hormone problem and prescribed medication. Levothyroxine for hypothyroidism, felimazole or radioactive iodine for hyperthyroidism, trilostane for Cushing’s, fludrocortisone and prednisolone for Addison’s. This medication is justified and necessary for most conditions for life. But in an average consultation, there is no room to explain why endocrine disorders are so much more than a hormone problem, and why an animal that is well adjusted to medication still remains fatigued, loses muscle mass or is susceptible to infections. <\/p>\n

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What your vet may not have explained<\/p>\n

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\u2192<\/span>Hormones send, but the body reacts. In endocrine disorders, the body loses its ability to adapt: it can no longer respond adequately to changes. <\/div>\n
\u2192<\/span>Medication restores hormonal control but does not repair the secondary damage: mitochondrial exhaustion, oxidative stress, muscle loss, and intestinal dysregulation that has caused years of dysregulation.<\/div>\n
\u2192<\/span>The gut-hormone axis: a significant part of the peripheral T4-to-T3 conversion occurs via gut microbiome enzymes. A disturbed microbiome reduces active thyroid hormone status even with adequate levothyroxine dosing. <\/div>\n
\u2192<\/span>Chronically elevated cortisol in Cushing’s directly damages mitochondrial membranes. Animals that are well adjusted to trilostane often suffer from the mitochondrial damage that has been suffered for months. <\/div>\n
\u2192<\/span>With Addison’s, lifelong hormone replacement is non-negotiable, but the quality of life also depends on how well the body handles daily stress loads. Stress resilience must be built up in addition to the medication. <\/div>\n
\u2192<\/span>We don’t send hormones. We support how the body adapts. <\/div>\n<\/div>\n<\/div>\n

Nutrition for endocrine disorders<\/h2>\n

In endocrine disorders, nutrition is rarely discussed as a therapeutic tool. From the point of view of integrative medicine, this is a missed opportunity. <\/p>\n

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Our nutritional advice for endocrine disorders<\/p>\n

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No ultra-processed dry food.<\/strong> Ultra-processed foods increase glycemic load, enhance dysbiosis, and increase systemic LPS load which activates the HPA axis via TLR4 and further disrupts hormone balance. In Cushing’s case, high glycemic load increases the insulin resistance that is already present. In hypothyroidism, poor diet quality lowers mitochondrial energy production that is already reduced. <\/div>\n
High-quality fresh meat food as a basis.<\/strong> Fresh varied protein sources provide the amino acid precursors for hormone production (tyrosine for thyroid hormones and dopamine, tryptophan for serotonin), the cofactors for enzymatic conversions (iodine, selenium, zinc) and fermentable fibers for microbiome repair via the gut-hormone axis.<\/div>\n
Adequate protein intake for muscle maintenance.<\/strong> In Cushing’s and hyperthyroidism, muscle loss via catabolic hormone action is a primary problem. Adequate protein intake is the most direct dietary intervention to inhibit muscle breakdown. <\/div>\n
Predictable meal times.<\/strong> At Addison’s, a fixed daily structure supports the HPA axis by reducing the allostatic load. In insulin-resistant Cushing’s patients, fixed meal timing stabilizes the glucose and insulin cycle. <\/div>\n<\/div>\n<\/div>\n

Three Common Endpoints in All Endocrine Disorders<\/h2>\n
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Loss of adaptability<\/div>\n

The body can no longer respond adequately to stressors. HPA axis dysregulation or exhaustion is the central mechanism, regardless of the specific condition. <\/p>\n<\/div>\n

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Mitochondrial Exhaustion<\/div>\n

T3 directly regulates mitochondrial gene expression. Cortisol damages mitochondrial membranes in chronic elevation. In all four disorders, cellular energy production is structurally reduced. <\/p>\n<\/div>\n

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Gut hormone axis<\/div>\n

The microbiome modulates the HPA axis via short-chain fatty acids, regulates T4-to-T3 conversion via deiodinase enzymes, and influences the estrogen cycle. Dysbiosis undermines hormonal feedback on several levels at the same time. <\/p>\n<\/div>\n<\/div>\n

Our advice: phased support in addition to your vet’s medication<\/h2>\n

The phasing is mechanistically: first stabilize the intestine and the immune system, then build up adaptation and stress resistance, then restore the mitochondria. Each phase lays the foundation for the next. <\/p>\n

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<\/p>\n

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1<\/div>\n
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Phase 1: Bowel and system stabilization, weeks 1 to 6<\/div>\n
Laying the foundation for hormone balance starts in the gut<\/div>\n<\/div>\n<\/div>\n

A significant part of the peripheral T4-to-T3 conversion occurs via gut microbiome enzymes. A disturbed microbiome lowers the active thyroid hormone status even with adequate medication. LPS from a disturbed intestinal barrier activates the HPA axis via TLR4 and strengthens the stress axes that are already dysregulated in all four conditions. Liposomal curcumin modulates NF-kB and inhibits pro-inflammatory cytokine production that lowers hormone receptor sensitivity. <\/p>\n

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We advise in phase 1<\/div>\n
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\u2192<\/span> Prebiotics<\/div>\n
\u2192<\/span> Biofilm Balance<\/div>\n
\u2192<\/span> Liposomal Vitamin C<\/div>\n
\u2192<\/span> Liposomal Curcumin<\/div>\n<\/div>\n<\/div>\n<\/div>\n

<\/p>\n

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2<\/div>\n
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Phase 2: Adaptation, stress regulation and inflammatory balance, weeks 6 to 14<\/div>\n
Restoring HPA axis and building stress resilience<\/div>\n<\/div>\n<\/div>\n

Myco Adaptogen Complex supports the HPA axis via beta-glucans that modulate macrophage balance and indirectly dampen cortisol reactivity. Adaptogen Complex restores cortisol receptor sensitivity via ashwagandha and inhibits energetic exhaustion in chronic stress stress via rhodiola. Please note: the adaptogen complex is not used in untreated hyperthyroidism because of its potential stimulating effect on the thyroid gland. PEA & Boswellia inhibit neuroinflammation and support comfort and resilience. Omega-3 protects cell membranes and hormone receptors. <\/p>\n

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We advise in phase 2<\/div>\n
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\u2192<\/span> Myco Adaptogen Complex<\/div>\n
\u2192<\/span> Adaptogen Complex*<\/div>\n
\u2192<\/span> PEA Complex<\/div>\n
\u2192<\/span> Omega Blend<\/div>\n<\/div>\n

* Do not use Adaptogen Complex for untreated hyperthyroidism.<\/p>\n<\/div>\n<\/div>\n

<\/p>\n

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3<\/div>\n
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Phase 3: Mitochondrial repair and maintenance, weeks 14 to 22<\/div>\n
Cellular energy recovery after years of hormonal dysregulation<\/div>\n<\/div>\n<\/div>\n

T3 directly regulates the expression of mitochondrial genes. In hypothyroidism, mitochondrial activity is structurally reduced. In Cushing’s, chronic cortisol has damaged the mitochondrial membranes. In hyperthyroidism, chronic overactivity has depleted mitochondrial capacity. Longevity Support restores sirtuin activity and mitochondrial biogenesis through NAD\u207a. CoQ10 restores the electron transport chain that is affected in all four conditions. Glutathione lowers oxidative stress which reduces hormone receptor sensitivity. <\/p>\n

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We advise in phase 3<\/div>\n
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\u2192<\/span> Longevity Support<\/div>\n
\u2192<\/span> Liposomal CoQ10<\/div>\n
\u2192<\/span> Liposomal Glutathione<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

<\/p>\n

What can you expect and when?<\/h2>\n

Endocrine disorders are chronic. Hormone medication sets up the system, but systemic recovery takes more time. Always focus on the blood values your vet checks, not just clinical improvement. <\/p>\n

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Weeks 1-6<\/div>\n

Intestine stabilized. Better absorption of medication and nutrients. Less fluctuating energy. <\/p>\n<\/div>\n

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Week 6-14<\/div>\n

Stress resilience improves. Less extreme reactions to stimuli. Quieter basic level. Muscle quality recovers gradually. <\/p>\n<\/div>\n

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Week 14-22<\/div>\n

Mitochondrial recovery visible in vitality and resilience. Hormone medication works more efficiently. <\/p>\n<\/div>\n

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Month 6+<\/div>\n

Systemic recovery consolidated. Stable hormonal balance with medication and support together. <\/p>\n<\/div>\n<\/div>\n

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Always inform your veterinarian about the supplementation. With Addison: never adjust without consultation. In Cushing’s: check liver values when used trilostane, Longevity Support and CoQ10 support the liver load of this drug. In case of hyperthyroidism: Do not use Adaptogen Complex until after treatment and stabilization. <\/p>\n<\/div>\n

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Specific points of attention for each condition<\/h2>\n
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Hypothyroidism (dog)<\/div>\n

Levothyroxine is the basis. The beam supports T4-to-T3 conversion via intestinal repair, the mitochondrial energy production that normally regulates T3 and muscle maintenance affected by slowed metabolism. <\/p>\n

+<\/span> Fully deploy all phases<\/div>\n<\/div>\n
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Hyperthyroidism (cat)<\/div>\n

Felimazole or I-131 is leading. Focus on muscle maintenance through omega-3 and protein-rich foods. Mitochondrial recovery after exhaustion period. Only use Adaptogen Complex after treatment and stabilization. <\/p>\n

!<\/span> Adaptogen Complex: only after treatment<\/div>\n<\/div>\n
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Cushing’s disease<\/div>\n

Trilostane is leading. Focus on muscle preservation, insulin resistance support, and mitochondrial recovery after chronic cortisol damage. CoQ10 also supports the liver burden of trilostane. <\/p>\n

+<\/span> Consider Para Reset in case of present insulin resistance<\/div>\n<\/div>\n
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Addison’s disease<\/div>\n

Lifelong hormone replacement is non-negotiable. Focus on stress resilience, electrolyte balance and quality of life. Myco Adaptogen Complex supports HPA-axis resilience in addition to the medication. <\/p>\n

!<\/span> Never adjust without consulting a veterinarian<\/div>\n<\/div>\n<\/div>\n

<\/p>\n

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For which situations do we recommend this bundle?<\/p>\n

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\u2713<\/span>Hypothyroidism in dogs: supplemental to levothyroxine<\/div>\n
\u2713<\/span>Hyperthyroidism in cats: after treatment and stabilization<\/div>\n
\u2713<\/span>Cushing’s disease: complementary to trilostane<\/div>\n
\u2713<\/span>Addison’s disease: complementary to lifelong substitution<\/div>\n
\u2713<\/span>Fatigue and muscle loss despite good hormone setting<\/div>\n
\u2713<\/span>Subclinical hormonal dysregulation without formal diagnosis<\/div>\n<\/div>\n<\/div>\n
[trustindex no-registration=”google”]<\/div>\n
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Want to read the full scientific background?<\/p>\n

Stefan Veenstra DVM explains how the HPA axis, HPT axis, gut-hormone axis and mitochondrial exhaustion are related in endocrine disorders.<\/p>\n<\/div>\n

Read the article<\/a><\/p>\n<\/div>\n

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All supplements in this bundle<\/p>\n

\u2192<\/span> Prebiotics<\/a>
\n\u2192<\/span> Enzyme Mix 2<\/a>
\n\u2192<\/span> Liposomal Vitamin C<\/a>
\n\u2192<\/span> Liposomal Curcumin<\/a>
\n\u2192<\/span> Myco Adaptogen Complex<\/a>
\n\u2192<\/span> Adaptogen Complex<\/a>
\n\u2192<\/span> PEA & Boswellia<\/a>
\n\u2192<\/span> Omega-3 Calanus Oil<\/a>
\n\u2192<\/span> Longevity Support<\/a>
\n\u2192<\/span> Liposomal CoQ10<\/a>
\n\u2192<\/span> Liposomal Glutathione<\/a><\/div>\n<\/div>\n
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SV<\/div>\n

Developed and clinically substantiated by Stefan Veenstra DVM<\/strong>, integrative veterinarian and founder of NGD Care. For personal guidance: NGD Care consultation \u2192<\/a> <\/p>\n<\/div>\n

This bundle is educational in nature and does not replace a veterinary consultation. The Endocrine Bundle is intended as a supplement to regular veterinary treatment, never as a replacement. Always use in consultation with your veterinarian. Always schedule a personal consultation with Addison and with unstable Cushing’s. <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Additional supplementation support in hypothyroidism, hyperthyroidism, Cushing’s and Addison’s in dogs and cats. Supports adaptive capacity, gut-hormone axis and mitochondrial repair in addition to hormonal medications. <\/p>\n","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"wds_primary_product_brand":0,"wds_primary_product_cat":0,"wds_primary_merken":0,"_members_access_role":[],"_members_access_error":""},"product_brand":[],"product_cat":[13839,13862],"product_tag":[14261,1147,14253,14259,505,14251,14262,14255,5403,14249,14247,6107,14257],"merken":[],"class_list":["post-24722","product","type-product","status-publish","product_cat-bundles","product_cat-hormones-endocrine","product_tag-adaptability","product_tag-adaptogens","product_tag-addison","product_tag-adrenal-gland","product_tag-ashwagandha-en","product_tag-cushings","product_tag-gut-hormone-axis","product_tag-hormone-balance","product_tag-hpa-axis","product_tag-hyperthyroidism","product_tag-hypothyroidism","product_tag-mitochondria-2","product_tag-thyroid-gland","infinite-scroll-item","sales-flash-overlay","woocommerce-text-align-center","woocommerce-image-align-center","do-quantity-buttons","first","instock","taxable","shipping-taxable","product-type-mpb_multi_product_bundle"],"meta_box":[],"_links":{"self":[{"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/product\/24722","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/comments?post=24722"}],"wp:attachment":[{"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/media?parent=24722"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/product_brand?post=24722"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/product_cat?post=24722"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/product_tag?post=24722"},{"taxonomy":"merken","embeddable":true,"href":"https:\/\/www.ngdcare.nl\/en\/wp-json\/wp\/v2\/merken?post=24722"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}