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The NGD Care Joint Support Program<\/strong> supports dogs and cats with stiff standing up, difficulty climbing stairs, joint pain, osteoarthritis and joint wear. The process addresses both the pain and the underlying cause: the chronic inflammation that breaks down cartilage. Can also be used preventively in large breeds and active dogs. <\/p>\n<\/div>\n Joint pain in dogs and cats has two components that both need to be addressed: the inflammation that damages the joint, and the loss of cartilage that results from that inflammation. A supplement that only inhibits pain does not address the cause. A supplement that only provides nutrients has limited effect if the inflammation breaks down the cartilage faster than it can be built up. <\/p>\n Osteoarthritis is a systemic disease of the joint in which several processes are disrupted at the same time: MMP enzymes<\/a> break down collagen, pro-inflammatory cytokines maintain inflammation, activated synovial macrophages<\/a> feed the cytokine cascade and mitochondria in chondrocytes<\/a> become exhausted. A single supplement can only address one of these processes. <\/p>\n The NGD Care Joint Support Trajectory<\/strong> is therefore divided into four layers that build on each other: bowel repair as a systemic inflammatory basis in chronic osteoarthritis, preventive for those who want to prevent wear and tear, supplemented with pain modulation in pain, and extended to the full systemic trajectory in chronic osteoarthritis.<\/p>\n In chronic osteoarthritis, we recommend starting with the Bowel Recovery Trajectory, as a supplement to the systemic inflammatory pressure. The three layers thereafter build on each other: the preventive foundation lays the cartilage foundations and inhibits low-grade wear, pain modulation is added in case of pain, and in chronic osteoarthritis, the pathway is expanded to include direct MMP inhibition, synovial immune repair, and mitochondrial support of chondrocytes. <\/p>\n In the case of chronic osteoarthritis, we recommend starting the Bowel Recovery Process<\/a> in addition to this process. Chronic low-grade inflammation is partly driven by endotoxins (LPS) that reach the bloodstream with increased intestinal permeability and activate the synovial macrophages via TLR4 and NF-kB. In the case of persistent osteoarthritis despite the chronic layer, intestinal repair is therefore a useful addition to the systemic inflammatory pressure. <\/p>\n <\/p>\n Mobility Support<\/a> provides the complete cartilage matrix via eggshell membrane: collagen type II, hyaluronic acid and the growth factors IGF-1 and TGF-beta. This is the structural basis, also preventive, because cartilage does not have its own blood vessels and can only be built up if the building materials are structurally available. O-Mega Blend<\/a> provides calanus oil, a sustainably sourced omega-3 source that inhibits the COX pathway that drives MMP activation in cartilage via EPA, DHA, and stearidonic acid, and maintains the quality of the synovial fluid. Histamine Balance<\/a> combines MSM and quercetin: MSM provides bioavailable sulfur as a building material for the cartilage matrix, quercetin inhibits low-grade joint inflammation via NF-kB that accelerates wear and tear. Recommended for large breeds from two years of age, for active dogs and dogs with dysplasia predisposition. <\/p>\n <\/p>\n In case of visible pain, stiffness or reluctant movement, the preventive layer is expanded with PEA Complex<\/a>. PEA modulates pain via PPAR-alpha activation and inhibits mast cell activation in joint tissue without the side effects of long-term NSAID use. Effect noticeable within one to two weeks. PEA works synergistically with the omega-3 in O-Mega Blend: both inhibit the prostaglandin cascade on complementary pathways. For pain with a strong central or stress-related component, supplemental CBD oil<\/a> is an option. <\/p>\n <\/p>\n In the case of chronic osteoarthritis, the entire process is started with three additions, each of which addresses a different level of the cascade. Liposomal Curcumin<\/a> inhibits NF-kB and directly MMP-13, the enzyme that breaks down collagen type II. This makes curcumin mechanistically more relevant than CBD in osteoarthritis: curcumin inhibits structural cartilage breakdown, CBD mainly modulates pain perception. Myco Immune Complex<\/a> modulates the synovial macrophages that maintain the cytokine cascade via beta-glucans. Activated M1 macrophages in the synovial fluid are the central driver of chronic joint inflammation; beta-glucans direct macrophage polarization towards the anti-inflammatory M2 phenotype and inhibit NF-kB and MAPK at the synovial level. Liposomal Coenzyme Q10<\/a> restores mitochondrial energy production in chondrocytes: without sufficient ATP, chondrocytes cannot convert the building blocks of Mobility Support into cartilage repair. In long-term chronic use, supplemental Shilajit<\/a> is an option: a human RCT (2024) showed stimulation of type 1 collagen synthesis; fulvic acid synergistically supports mitochondrial biogenesis with CoQ10. Veterinary RCT data in dogs are still lacking. <\/p>\n Joint repair occurs via two time scales. Pain modulation responds quickly via PEA and omega-3. Cartilage build-up is a slow biological process because cartilage does not have its own blood vessels. Give the entire process at least three months for an honest assessment of the structural effect. <\/p>\n PEA modulates pain. Fewer pain reactions when moving. Easier to get up. More willingness to be active. <\/p>\n<\/div>\n Clearly less stiffness after halftime. Move more smoothly. Less restraint when climbing stairs and jumping. <\/p>\n<\/div>\n Structural cartilage repair via Mobility Support and CoQ10. Better synovial fluid quality. More desire to play and vitality. <\/p>\n<\/div>\n Daily maintenance inhibits further wear. In osteoarthritis, this is a long-term process. Possible reduction of NSAIDs in consultation with veterinarian. <\/p>\n<\/div>\n<\/div>\n Don’t see any improvement after six weeks? Schedule an intake with Stefan Veenstra. Never adjust the process without consulting a veterinarian if your animal is also taking NSAIDs. <\/p>\n<\/div>\nWhy a program and not a single joint supplement?<\/h2>\n
How does the Joint Support Program work?<\/h2>\n
\n\u2192<\/span>O-Mega Blend<\/a>
\n\u2192<\/span>Histamine Balance<\/a><\/div>\n<\/div>\n<\/div>\n
\n\u2192<\/span>CBD oil<\/a><\/div>\n<\/div>\n<\/div>\n
\n\u2192<\/span>Myco Immune Complex<\/a>
\n\u2192<\/span>Liposomal Coenzyme Q10<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\nWhen do you see results?<\/h2>\n
Why the NGD Care Joint Support Program?<\/h2>\n