Liposomal curcumin extract

Dosage and use

• Dosage
  • based on scientific literature.
  • <4 years only under medical supervision
  • 4-12 years
    • maintenance dose 1x daily 1/2 capsule
    • increased need 1x daily 1 capsule
  • 12-18 years
    • maintenance 1x daily 1 capsules
    • increased need 2x daily 1 capsules
  • Adults
    • maintenance 1x daily 1 capsules
    • increased need 2x daily 1 capsules
    • Therapeutic dosage (max 4-6 weeks in consultation with doctor or therapist) 2x daily 2 capsules
• Manual
  • With meals in the morning and/or afternoon.
  • Not on an empty stomach with a sensitive stomach.
  • Store in a dry, sealed and room temperature.
• Allergy information
  • Allergen-free: free from gluten, soy, nuts, egg, fish, shellfish
• Contraindications
  • Turmeric has a blood-thinning effect. Use before surgery is not recommended, as is use with anticoagulant medication.
  • Turmeric can increase bile production, in case of a gallbladder infection or gallstones its use is not recommended.
• Side effects
  • Reflux, mild diarrhea.
• Interactions
  • Curcumin is known for its influence on multiple phase I and phase II enzymes. In vitro and in animal models, inhibitory effects have been described on several CYP450 subtypes, including CYP3A4, CYP1A1/2, CYP2C9 and CYP2D6. This means that curcumin can theoretically slow the clearance of drugs metabolized by these enzymes, such as certain anticoagulants (including warfarin), some antidepressants, antipsychotics, calcium channel blockers, and immunosuppressants. The clinical relevance is especially important for drugs with a narrow therapeutic breadth.
  • In addition, curcumin inhibits COX-2 and 5-LOX, among others, and affects NF-κB signaling, which can make it anti-inflammatory and change the need for NSAIDs. In combination with anticoagulant medications (DOACs, coumarins), an additive effect on bleeding risk cannot be excluded, partly by influencing platelet aggregation and prostaglandin synthesis.
  • Curcumin can also modulate the expression of transporters such as P-gp, OATP, and BCRP, which can alter the absorption and distribution of certain drugs. This is especially relevant with oral chemotherapeutics, digoxin and some antiviral drugs. In the oncological context and in polypharmacy, it is therefore preferable to discuss curcumin use with the treating physician.